Access & Contact

Project Chief.
Kunitada Shimotohno

Research Center for Hepatitis and Immunology National Center for Global Health and Medicine

1-7-1 Kohnodai Ichikawa 272-8516, Chiba, Japan

81-47-375-4742 (ext 1435)
81-47-375-4750 (direct)


mail address:

About Research

Some infectious agents, such as viruses and bacteria, are known to cause cancer. It is estimated that relatively large percentage of cancers in the world are related to microbe infection. These include: human papilloma virus (HPV), Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human herpes virus type 8 (HHV8), or the bacteria, Helicobacter pylori as well as others.In Japan, approximately 300,000 people die of cancer every year. Around 13% of cancer deaths is believed to be caused by viruses. Approximately 10% of the virus related cancers are hepatocellular carcinoma (HCC), caused by either HBV or HCV infection.

Among the hepatitis viruses, we are focusing on HCV and HBV. We are especially interested in elucidating virus replication strategies to establish the methods to prevent and eliminate virus infection and proliferation. Moreover, we wish to clarify the mechanisms by which HCV-derived HCC is caused in order to prevent cancer development.


Recent research(02/14)

The following works were reported recently by our group.